Publications by authors named "K Aleksandrova"
Experimental research has uncovered lipocalin 2 (LCN2) as a novel biomarker implicated in the modulation of intestinal inflammation, metabolic homeostasis, and colon carcinogenesis. However, evidence from human research has been scant. We, therefore, explored the association of pre-diagnostic circulating LCN2 concentrations with incident colorectal cancer (CRC) in a nested case-control study within the in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
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- The introduction highlights the rapid growth of point-of-care (POC) manufacturing for chimeric antigen receptor (CAR) modified T cells, particularly focusing on anti-CD20 CAR T cells for melanoma patients in a phase I clinical trial.
- The methods used involved producing CD20 CAR T cells using a second-generation lentiviral vector on the CliniMACS Prodigy® platform, demonstrating high purity and functionality across two production sites.
- Results confirmed a sufficient expansion and activation capability of the CAR T cells, revealing interindividual differences in their response, thereby supporting the effectiveness of the CliniMACS Prodigy® for decentralized CAR T cell manufacturing.
Article Synopsis
- The study investigated the links between saturated and unsaturated fatty acids and cardiovascular disease (CVD), focusing on conditions like coronary heart disease (CHD) and stroke in a large group of participants.
- Results showed that higher levels of saturated fatty acids were linked to increased CVD risks, with specific subtypes having varying effects on CHD and stroke.
- Conversely, higher concentrations of certain polyunsaturated fatty acids (both n-3 and n-6 types) were associated with lower risks of CHD and stroke, suggesting dietary fats play a significant role in cardiovascular health.
Article Synopsis
- The study examines how traditional dietary assessments may fall short in accurately measuring children's intake of sweet and fatty snacks, which can contribute to obesity and health issues in childhood.
- Researchers analyzed urine samples from children in two different cohorts to identify metabolite biomarkers that correlate with the consumption of snacks like chocolate, candy, and ice cream.
- A total of 66 metabolites were linked to snack consumption, with associations found for specific types of snacks; however, many metabolites could not be specifically identified.
Background: A number of biomarkers denoting various pathophysiological pathways have been implicated in the aetiology and risk of age-related diseases. Hence, the combined impact of multiple biomarkers in relation to ageing free of major chronic diseases, such as cancer, cardiovascular disease and type 2 diabetes, has not been sufficiently explored.
Methods: We measured concentrations of 13 biomarkers in a random subcohort of 2,500 participants in the European Prospective Investigation into Cancer and Nutrition Potsdam study.