Publications by authors named "K Akuta"
A resident vascular endothelial stem cell (VESC) population expressing CD157 has been identified recently in mice. Herein, we identified transcription factors (TFs) regulating CD157 expression in endothelial cells (ECs) that were associated with drug resistance, angiogenesis, and EC proliferation. In the first screening, we detected 20 candidate TFs through the promoter and gene expression analyses.
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- * The study using APJ knock out (KO) mice revealed that apelin overexpression in melanoma cells led to increased tumor growth despite reduced angiogenesis, indicating complex interactions in tumor biology.
- * APJ deficiency was associated with changes in cell shape, hinting at a process called epithelial-mesenchymal transition (EMT), though it did not show a clear relationship with a specific signaling pathway, suggesting that the apelin-APJ system may promote tumor growth but limit EMT and cancer aggressiveness.
Article Synopsis
- * Two heavily treated elderly patients responded well to this sequential therapy, achieving complete molecular remission without severe side effects typically associated with other treatments.
- * The therapy shows potential as a bridging regimen before allogeneic stem cell transplantation, although further preventative measures for central nervous system issues are recommended.
Autoimmune hematological disorders are rare complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Diagnosis of immune thrombocytopenia (ITP) is challenging, especially after allo-HSCT, because various complications such as graft-versus-host disease, disease relapse, viral infection, thrombotic microangiopathy, and drug side effects can also cause thrombocytopenia. Assessment of reticulated platelets (RP) and plasma thrombopoietin (TPO) levels may be useful to distinguish between ITP and hypoplastic thrombocytopenia.
View Article and Find Full Text PDFPurpose: To assess prebiopsy characteristics influencing the occurrence of pneumothorax after first puncture of ultrasound (US)-guided lung biopsy with coaxial technique.
Materials And Methods: From January 2007 to September 2018, 180 peripheral lung lesions in 174 patients who underwent B-mode US-guided lung biopsy with coaxial technique at single institution were included in this study. Technical success was defined as the ability to make a diagnosis using the acquired sample with/without an adverse event of pneumothorax.