Publications by authors named "K Akesson"
Treatment regimens and glycaemic outcomes in more than 100 000 children with type 1 diabetes (2013-22): a longitudinal analysis of data from paediatric diabetes registries.
Lancet Diabetes Endocrinol
January 2025
Background: Advances in paediatric type 1 diabetes management and increased use of diabetes technology have led to improvements in glycaemia, reduced risk of severe hypoglycaemia, and improved quality of life. Since 1993, progressively lower HbA targets have been set. The aim of this study was to perform a longitudinal analysis of HbA, treatment regimens, and acute complications between 2013 and 2022 using data from eight national and one international paediatric diabetes registries.
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- - The guidelines update the International Osteoporosis Foundation's (IOF) 20-year-old position paper on bone markers, reflecting advancements in bone biology and disorders.
- - The authors introduce a new classification called Bone Status Indices (BSI) to replace outdated terms like bone turnover markers and metabolic markers for better clarity.
- - The proposal includes standardized nomenclature, abbreviations, and measurement units for these indices to ensure consistency in the study and treatment of bone health.
Children who develop diabetes in their first years of life risk being exposed to many decades of hyperglycemia, hence having a high risk of early complications and premature death. An additional age-dependent risk is that dysglycemia, especially hyperglycemia, negatively affects the developing brain. In evaluating the outcome of insulin treatment at an individual and group level, cutoff thresholds for glucose values are needed.
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- The study aimed to compare bone mineral density (BMD) and osteoporosis rates in systemic sclerosis (SSc) patients to those in a general population, highlighting specific SSc-related factors influencing BMD.
- It involved 211 SSc patients (majority women) and 505 control participants, measuring BMD at the hip and lumbar spine using X-ray technology, with specific criteria for osteopenia and osteoporosis.
- Results showed significantly lower BMD in SSc patients, particularly women, with factors like age, BMI, menopause, and certain SSc symptoms (like finger ulcers) contributing to decreased BMD, highlighting the need for bone health evaluations in all SSc patients.
Aims/hypothesis: To study the progression of HbA1c after diagnosis of type 1 diabetes in children and adolescents during 2010-2019 with emphasis on HbA1c nadir 3-6 months after onset.
Methods: Partial funding was secured for this study. The Swedish paediatric diabetes quality register SWEDIABKIDS has >95 % coverage of type 1 diabetes up to 18 years.