Publications by authors named "K Ajgeiy"
Whether response to an interleukin (IL-17) inhibitor is different in patients with previous exposure to an IL-17 inhibitor compared with patients with exposure to biologics with other cytokine targets remains to be elucidated. Therefore, the aim of this study was to assess whether previous exposure to an IL-17A inhibitor was associated with worse response than exposure to (an)other biologic(s). All patients in the DERMBIO register treated with an IL-17A inhibitor (secukinumab or ixekizumab) were included.
View Article and Find Full Text PDFDrug survival of biologic therapies for palmoplantar pustulosis: A nationwide study.
J Eur Acad Dermatol Venereol
February 2024
Article Synopsis
- Biological therapies are effective for psoriasis vulgaris but face challenges in treating palmoplantar pustulosis (PPP), with limited data on their effectiveness over time.
- A study analyzing a Danish registry from 2007 to 2019 found that out of 85 patients undergoing biologic treatment for PPP, 77.8% of treatment courses were discontinued, primarily due to ineffective responses.
- Ustekinumab had the longest median drug survival at 14.6 months, while overall median drug survival for all therapies was 9.3 months, highlighting the difficulties in managing PPP effectively.
Article Synopsis
- The study aimed to evaluate the real-world effectiveness of biologics in treating psoriasis by looking at treatment discontinuation and off-label dose escalation, rather than relying solely on traditional drug survival studies.
- Researchers analyzed data from a nationwide registry (DERMBIO) involving patients treated with adalimumab, secukinumab, and ustekinumab from 2007 to 2019, focusing on composite, discontinuation, and escalation outcomes.
- Findings indicated that secukinumab had a lower overall risk of treatment discontinuation compared to ustekinumab, but a higher risk for discontinuation when compared to adalimumab, with bio-naive patients on secukinumab showing a similar discontinuation risk as those
Background: Immunosuppressive agents may increase the risk of infections with human alphaherpesviruses.
Methods: We included all adult patients with moderate to severe psoriasis who initiated methotrexate (MTX) or biologic agents in a retrospective cohort study. An episode of alphaherpesviruses infection was defined as filling a prescription for systemic acyclovir, valacyclovir, or famciclovir.