Publications by authors named "K Aiba"
Article Synopsis
- Transient neonatal zinc deficiency (TNZD) occurs in breastfed infants due to low zinc levels in breast milk, which can be linked to mutations in the ZNT2 gene responsible for zinc transport.
- The study focused on three Japanese mothers with infants affected by TNZD, using sequencing to identify genetic mutations affecting zinc levels.
- Novel mutations were found, including a missense mutation impacting zinc transport and others in the regulatory region, offering new insights into the genetic causes of TNZD in breastfeeding.
Purpose: Cerebrospinal-fluid drainage (CSFD) has been performed to prevent paraplegia in descending thoracic or thoraco-abdominal aortic aneurysm (DTA/TAAA) surgery; however, CSFD itself has a risk of severe complications. We retrospectively investigated the incidence rates of CSFD-related preoperative and postoperative complications.
Methods: Patients who underwent DTA/TAAA surgery with a CSFD catheter that was inserted on the day before surgery were enrolled.
Article Synopsis
- Alpha-thalassemia X-linked intellectual disability (ATR-X) syndrome is linked to mutations in the ATRX gene, crucial for chromatin remodeling, leading to gene dysregulation and a multisystem disorder in affected individuals.
- A study of a 4-year-old boy with a specific ATRX mutation showed signs of mitochondrial dysfunction, particularly a deficiency in complex I of the mitochondria.
- The findings indicate that ATRX might influence mitochondrial function and that this dysfunction could play a role in the symptoms associated with ATR-X syndrome.
Intraoperative massive bleeding is associated with high rates of mortality and anesthetic management of massive bleeding is challenging because it is necessary to achieve volume resuscitation and electrolyte correction simultaneously during massive transfusion. We report a case of life-threatening bleeding of more than 80,000 mL during liver transplantation in which real-time QTc monitoring was useful for an extremely large amount of calcium administration for treatment of hypocalcemia. A 47-year-old female with a giant liver due to polycystic liver disease was scheduled to undergo liver transplantation.
View Article and Find Full Text PDFBackground: The ACTS-CC 02 trial demonstrated that S-1 plus oxaliplatin (SOX) was not superior to tegafur-uracil and leucovorin (UFT/LV) in terms of disease-free survival (DFS) as adjuvant chemotherapy for high-risk stage III colon cancer (any T, N2, or positive nodes around the origin of the feeding arteries). We now report the final overall survival (OS) and subgroup analysis according to the pathological stage (TNM 7th edition) for treatment efficacy.
Patients And Methods: Patients who underwent curative resection for pathologically confirmed high-risk stage III colon cancer were randomly assigned to receive either UFT/LV (300 mg/m of UFT and 75 mg/day of LV on days 1-28, every 35 days, five cycles) or SOX (100 mg/m of oxaliplatin on day 1 and 80 mg/m/day of S-1 on days 1-14, every 21 days, eight cycles).