Scopolamine increases nonreinforced behavior in an intracranial self-stimulation discrimination paradigm.

The effects of several doses of systemic scopolamine administration on brain-stimulation reward from the A10 nucleus of the ventral tegmental area (VTA) were evaluated. The intracranial self-stimulation (ICSS) task involved a two-hole nose-poke procedure allowing for the assessment of both reinforced (correct) and nonreinforced (incorrect) performance levels as a function of varying current intensities. Scopolamine (0.