Publications by authors named "K Adam"
Working memory (WM) is an evolving concept. Our understanding of the neural functions that support WM develops iteratively alongside the approaches used to study it, and both can be profoundly shaped by available tools and prevailing theoretical paradigms. Here, the organizers of the 2024 Working Memory Symposium-inspired by this year's meeting-highlight current trends and looming questions in WM research.
View Article and Find Full Text PDFUnlabelled: While visual working memory (WM) is strongly associated with reductions in occipitoparietal 8-12 Hz alpha power, the role of 4-7 Hz frontal midline theta power is less clear, with both increases and decreases widely reported. Here, we test the hypothesis that this theta paradox can be explained by non-oscillatory, aperiodic neural activity dynamics. Because traditional time-frequency analyses of electroencephalopgraphy (EEG) data conflate oscillations and aperiodic activity, event-related changes in aperiodic activity can manifest as task-related changes in apparent oscillations, even when none are present.
View Article and Find Full Text PDFArticle Synopsis
- Cancer treatment is shifting towards immunotherapy, with immune checkpoint inhibitors (ICIs) showing promising results in improving patient survival rates.
- The FDA has recently approved a combination therapy involving LAG3 and PD1 inhibitors for advanced melanoma patients, paving the way for further research.
- Ongoing clinical trials are exploring new LAG3-targeted treatments, including bispecific antibodies that aim to reactivate exhausted T cells in the fight against cancer.
Background: Mutations in the gene can disrupt its normal signaling pathways, leading to hematological disorders such as polycythemia vera and other myeloproliferative diseases.
Methodology: In this study, a range of bioinformatics tools, including SIFT, PolyPhen-2, SNAP2, SNPs & Go, PhD-SNP, I-Mutant2.0, MuPro, MutPred, ConSurf, HOPE, and Interpro were used to assess the deleterious effects of missense nonsynonymous single nucleotide polymorphisms (nsSNPs) on protein structure and function.