A label-free DNAzyme-Mediated biosensor for fluorescent detection of Lead (II) ion.

Lead ion (Pb) is a common environmental contaminant, extremely toxic, persistent, and easily adsorbed, concentrated, and enriched by agricultural products. Ingestion of this ion can result in health problems for humans, including neurological disorders, heart disease, brain damage, and mental deficiency. In this research, a sensitive fluorescent biosensing method for detecting Pb was developed using DNAzyme as the target recognition element and SYBR Green (SG) fluorescent dye as the signal indicator.

An innovative biosensor utilizing aptamer-gated mesoporous silica nanoparticles for determination of aminoglycoside antibiotics through indirect-lateral flow.

Background: Aminoglycoside antibiotics (AGs) are commonly utilized in both human and veterinary medicine to treat and manage a range of infections. These antibiotics are recognized for their narrow therapeutic window, with an overdose potentially resulting in severe side effects like kidney and ear damage. Hence, the implementation of a quick, precise, and on-the-spot testing method is crucial in clinical settings.

A liquid crystal-decorated aptasensing gadget for rapid monitoring of A549 cells: Future portable test kit for lung cancer diagnosis.

Background: Presented here is a straightforward detection system designed to track non-small cell lung cancer (specifically A549 cells) using a combination of liquid crystals (LCs) and aptamer sequences, marking a pioneering approach in this field. A change in the alignment of LCs from perpendicular to random status by the aptamer-cell complex altered the murky polarized background of the aptasensor to multicolored.

Results: The LC-designed aptasensor could determine A549 cancerous cells in the range of 2.