Publications by authors named "K A van den Bosch"
Article Synopsis
- The study examines cachexia in cancer patients, which is a syndrome causing muscle and cardiac deterioration, and explores how withaferin A (WFA) treatment can help mitigate these effects.
- Researchers created a model by injecting NSG mice with ovarian cancer cells and treated them with WFA to assess its impact on kidney damage in addition to muscle and cardiac function.
- Results indicate that tumor-bearing mice exhibited elevated inflammatory markers and kidney damage, but WFA treatment significantly reduced these harmful effects compared to control groups.
Combination approaches are needed to strengthen and extend the clinical response to KRAS inhibitors (KRASi). Here, we assessed the antitumor responses of KRAS mutant lung and colorectal cancer models to combination treatment with a SOS1 inhibitor (SOS1i), BI-3406, plus the KRAS inhibitor, adagrasib. We found that responses to BI-3406 plus adagrasib were stronger than to adagrasib alone, comparable to adagrasib with SHP2 (SHP2i) or EGFR inhibitors and correlated with stronger suppression of RAS-MAPK signaling.
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- Autism is a common condition influenced by both single gene issues and multiple genes, and many autistic people need better healthcare that genomics can help provide.
- The European Autism GEnomics Registry (EAGER) aims to collect info about autistic people who have had their entire DNA sequenced to help with future research and trials.
- EAGER will involve 1,500 participants from 13 places in 8 countries who will share genetic samples and fill out surveys to help researchers understand the link between genetics and health.
Purpose: Renal transplantation (RT) is not recommended above BMI 40 kg/m as post-operative risks (delayed graft function, wound complications) are increased. Bariatric surgery (BS) results in sustained long-term weight loss. However, renal failure (RF) patients are theoretically higher risk candidates.
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- The study investigates how hydrogen peroxide (HO) affects protein function by reversible oxidation of thiols, emphasizing its role in cellular signaling.
- Researchers created a yeast library with a HO sensor (HyPer7) attached to proteins to identify locations of HO generation, alongside a control library with a mutant sensor.
- Results showed that HO availability varies significantly among different proteins and conditions, indicating that HO generation is more localized and nuanced than previously thought.