Publications by authors named "K A Zervides"
Article Synopsis
- Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect various organs, including the brain, and researchers used an AI model called BrainAGE to assess brain aging in SLE patients.
- The study involved 70 female SLE patients and 24 healthy controls, utilizing MRI scans and neuropsychological tests to calculate BrainAGE scores.
- Results showed that SLE patients had significantly higher BrainAGE scores than controls, which were linked to cognitive impairments like slower reaction times and lower mental flexibility, indicating potential neuronal damage.
Objective: Dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) has previously shown alterations in cerebral perfusion in patients with systemic lupus erythematosus (SLE). However, the results have been inconsistent, in particular regarding neuropsychiatric (NP) SLE. Thus, we investigated perfusion-based measures in different brain regions in SLE patients with and without NP involvement, and additionally, in white matter hyperintensities (WMHs), the most common MRI pathology in SLE patients.
View Article and Find Full Text PDFBackground: Neuronal damage in systemic lupus erythematosus (SLE) is common, but the extent and mechanisms are unclear. Neurofilament light (NfL) concentrations rise in plasma and cerebrospinal fluid (CSF) during neuronal damage in various neurological disorders. In this cross-sectional study, plasma and CSF concentrations of NfL were explored as a marker of neuronal damage in SLE.
View Article and Find Full Text PDFBackground: Neuropsychiatric (NP) involvement and fatigue are major problems in systemic lupus erythematosus (SLE). S100A8/A9 is a marker of inflammation and responds to therapy in SLE patients. S100A8/A9 has an immunopathogenic role in various neurological diseases.
View Article and Find Full Text PDFBackground: Previous research has provided evidence for cognitive dysfunction as a common symptom of systemic lupus erythematosus (SLE). In light of this, the primary goal of this study was to investigate how cognitive impairment in this patient group develops over time. In addition, the present dataset contributes to delineating the specific abilities that are impaired in SLE patients as well as answering the question whether the disease affects the cognition of SLE patients with neuropsychiatric manifestations (NPSLE) and without (non-NPSLE) in distinct ways.
View Article and Find Full Text PDF