Publications by authors named "K A Veiga"
The autoimmune disease lupus erythematosus (lupus) is characterized by photosensitivity, where even ambient ultraviolet radiation (UVR) exposure can lead to development of inflammatory skin lesions. We have previously shown that Langerhans cells (LCs) limit keratinocyte apoptosis and photosensitivity via a disintegrin and metalloprotease 17 (ADAM17)-mediated release of epidermal growth factor receptor (EGFR) ligands and that LC ADAM17 sheddase activity is reduced in lupus. Here, we sought to understand how the lupus skin environment contributes to LC ADAM17 dysfunction and, in the process, differentiate between effects on LC ADAM17 sheddase function, LC ADAM17 expression, and LC numbers.
View Article and Find Full Text PDFDeficiency of Adenosine Deaminase 2: Clinical Manifestations, Diagnosis, and Treatment.
Rheum Dis Clin North Am
November 2023
Article Synopsis
- DADA2 is a genetic condition caused by mutations in the adenosine deaminase 2 gene, leading to symptoms like skin inflammation and strokes.* -
- Diagnosis is confirmed through low ADA2 enzyme activity and genetic testing, with early hematologic issues like low immunoglobulin levels and reduced blood cell counts.* -
- Treatment includes using tumor necrosis factor inhibitors for inflammation and possibly hematopoietic stem cell transplants for severe cases.*
Aarskog-Scott syndrome (AAS) is characterized by different facial, skeletal and genital anomalies and may have oral manifestations. A 7-year-old boy was referred to the University General Hospital for treatment of speech difficulties and frequent regurgitation. Characteristics such as a triangle-shaped face, hypertelorism, low-set ears, flattened nose, shawl scrotum and partial syndactylia on hands and feet were observed.
View Article and Find Full Text PDFBackground: Recognition of the role of vitamin D in immune function has led to interest in its relationship with SARS-CoV-2 infection. Although clinical studies to date have had conflicting results, many individuals currently take high doses of vitamin D to prevent infection.
Objective: The goal of this study was to investigate the relationship between serum 25-hydroxyvitamin D (25OHD) and vitamin D supplement use with incident SARS-CoV-2 infection.
Objective: To provide updated guidelines for pharmacologic management of juvenile idiopathic arthritis (JIA), focusing on treatment of oligoarthritis, temporomandibular joint (TMJ) arthritis, and systemic JIA with and without macrophage activation syndrome. Recommendations regarding tapering and discontinuing treatment in inactive systemic JIA are also provided.
Methods: We developed clinically relevant Patient/Population, Intervention, Comparison, and Outcomes questions.