Publications by authors named "K A Todd"
Background: Understanding of the hemostatic and complement alterations associated with cardiopulmonary bypass (CPB) in pediatric patients and the impact of these alterations on outcome is limited.
Objectives: The present study prospectively characterized these alterations and their association with postoperative outcomes in pediatric CPB.
Methods: All patients aged <21 years undergoing CPB at the authors' institution between 2020 and 2021 who weighed >3 kg, were >36 weeks gestational age, and had no known prothrombotic or hemorrhagic disorders were eligible.
Severe febrile illnesses in children encompass life-threatening organ dysfunction caused by diverse pathogens and other severe inflammatory syndromes. A comparative approach to these illnesses may identify shared and distinct features of host immune dysfunction amenable to immunomodulation. Here, using immunophenotyping with mass cytometry and cell stimulation experiments, we illustrate trajectories of immune dysfunction in 74 children with multi-system inflammatory syndrome in children (MIS-C) associated with SARS-CoV-2, 30 with bacterial infection, 16 with viral infection, 8 with Kawasaki disease, and 42 controls.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to test the safety, tolerability, and pharmacokinetics of mirikizumab in 60 healthy Chinese adults, who were divided into five dosing groups receiving either the drug or a placebo.
- No serious side effects or deaths occurred; mild treatment-emergent adverse events (TEAEs) were reported in 56% of participants receiving the drug, compared to 80% in the placebo group.
- The pharmacokinetic results showed that higher IV doses led to a 3.5-fold increase in drug concentration metrics, while subcutaneous doses increased by 1.6-fold, with the drug remaining in the system for about 10 days.
Background: Despite increased recognition that structural racism contributes to poorer health outcomes for racial and ethnic minorities, there are knowledge gaps about how current patterns of racial residential segregation are associated with cancer screening uptake. The authors examined associations between Black residential segregation and screening for colorectal cancer (CRC) and cervical cancer among non-Hispanic Black and non-Hispanic White adults.
Methods: This was a retrospective study of CRC and cervical cancer screening-eligible adults from five health care systems within the Population-Based Research to Optimize the Screening Process (PROSPR II) Consortium (cohort entry, 2010-2012).