Dizziness and unstable gait in the older adults are associated with vestibular hypofunction, muscle dysfunction and sleep disturbance: impact on prevention of accidental falls.

Background: Dizziness and unstable gait with resultant falls are common symptoms among the older adults. Most of studies have focused on statistical analysis regarding single factor related to dizziness and unstable gait. On the other hand, there are very few comprehensive studies using a large number of patients except several review papers.

Extensive methylation analysis of circulating tumor DNA in plasma of patients with gastric cancer.

DNA methylation is known to be involved in tumor progression. This is the first study to perform an extensive methylation analysis of plasma circulating tumor DNA (ctDNA) using targeted bisulfite sequencing in gastric cancer (GC) patients to evaluate the usefulness of ctDNA methylation as a new biomarker. Sixteen patients who received chemotherapy for recurrent GC were included.

Recovery in Mother-To-Mother Peer Supporters Who Have Experienced Difficulties in Child-Rearing: A Phenomenological Study.

Aims: To elucidate the meaning of recovery for mothers who have experienced difficulties in child-rearing, using insights gained through their activities as mother-to-mother peer supporters.

Design: Phenomenological study.

Methods: From January to October 2022, semi-structured interviews were conducted with 11 mothers active as peer supporters at community child-rearing support centres in Japan.

WEE1 Confers Resistance to KRAS Inhibitors in Non-Small Cell Lung Cancer.

KRAS inhibitors sotorasib and adagrasib have been approved for the treatment of KRAS-mutant non-small cell lung cancer (NSCLC). However, the efficacy of single-agent treatments is limited, presumably due to multiple resistance mechanisms. To overcome these therapeutic limitations, combination strategies that potentiate the antitumor efficacy of KRAS inhibitors must be developed.

Structural insights into the engagement of lysophosphatidic acid receptor 1 with different G proteins.

Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are bioactive lysophospholipids derived from cell membranes that activate the endothelial differentiation gene family of G protein-coupled receptors. Activation of these receptors triggers multiple downstream signaling cascades through G proteins such as Gi/o, Gq/11, and G12/13. Therefore, LPA and S1P mediate several physiological processes, including cytoskeletal dynamics, neurite retraction, cell migration, cell proliferation, and intracellular ion fluxes.