How can we make therapy better for autistic adults? Autistic adults' ratings of helpfulness of adaptations to therapy.

Autistic people experience more mental health conditions like depression or anxiety than non-autistic people. They are also more likely to experience difficulties in accessing mental health supports Clinicians have published suggestions on how to improve therapy for autistic people. However, whether these ways to adapt (i.

Country-specific key lifestyle factors and health outcomes for resource allocation in the general population: a network analysis across 29 countries.

Background: We aimed to identify the central lifestyle, the most impactful among lifestyle factor clusters; the central health outcome, the most impactful among health outcome clusters; and the bridge lifestyle, the most strongly connected to health outcome clusters, across 29 countries to optimise resource allocation for local holistic health improvements.

Methods: From July 2020 to August 2021, we surveyed 16 461 adults across 29 countries who self-reported changes in 18 lifestyle factors and 13 health outcomes due to the pandemic. Three networks were generated by network analysis for each country: lifestyle, health outcome, and bridge networks.

Graded supplemental choline chloride fed throughout the grow and finish periods elicited minimal influence on growth performance and carcass characteristics of pigs in a commercial setting.

Choline is vital in a variety of physiological processes that influence brain development, growth, and carcass characteristics in birds and mammals. In this study, we investigated the influence of graded supplemental choline chloride on growth performance, carcass quality, and liver characteristics in grow-finish pigs. Pigs (672 barrows and 588 gilts) were obtained from a commercial nursery facility at 8 weeks of age and assigned to treatment based on body weight and sex, with 21 same-sex pigs comprising a replicate pen.

Targeting human plasma cells using regulated BCMA CAR T cells eliminates circulating antibodies in humanized mice.

Pathogenic long-lived plasma cells (LLPCs) secrete autoreactive antibodies, exacerbating autoimmune diseases and complicating solid organ transplantation. Targeted elimination of the autoreactive B cell pool represents a promising therapeutic strategy, yet current treatment modalities fall short in depleting mature PCs. Here, we demonstrate that chimeric antigen receptor (CAR) T cells, targeting B cell maturation antigen (BCMA) utilizing a split-receptor design, offer a controlled and effective therapeutic strategy against LLPCs.