Publications by authors named "K A Shepard"
Article Synopsis
- Two common intravenous medications for quick blood pressure control, nicardipine and clevidipine, were evaluated for their efficacy and safety in a hospital setting.
- A study involving 100 matched patient pairs found that clevidipine led to a significantly faster time to reach the target blood pressure range compared to nicardipine (20 minutes vs. 34 minutes).
- Although the percentage of time within the target blood pressure range was similar for both medications, nicardipine showed a non-significant trend toward a higher rate of hypotension.
Recent studies have demonstrated that the mechanisms through which biopolymers like RNA interconvert between multiple folded structures are critical for their cellular functions. A major obstacle to elucidating these mechanisms is the lack of experimental approaches that can resolve these interconversions between functionally relevant biomolecular structures. Here, we dissect the complete set of structural rearrangements executed by an ultra-stable RNA, the UUCG stem-loop, at the single-molecule level using a nano-electronic device with microsecond time resolution.
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- New brain-computer-interface (BCI) technology offers significant improvements in efficiency, featuring a thin and flexible micro-electrocorticography (μECoG) device with 256x256 electrodes.
- This innovative device integrates advanced components, allowing for the recording of up to 1024 brain signals simultaneously, all while being fully implanted and wirelessly powered.
- Successful tests in pigs and non-human primates demonstrated its ability to record brain activity reliably for extended periods, achieving high-quality data from critical brain areas related to sensory and motor functions.*
Discrete amplitude levels in ordered, time-domain data often represent different underlying latent states of the system that is being interrogated. Analysis and feature extraction from these data sets generally require considering the order of each individual point; this approach cannot take advantage of contemporary general-purpose graphics processing units (gpGPU) and single-instruction multiple-data (SIMD) instruction set architectures. Two sources of such data from single-molecule biological measurements are nanopores and single-molecule field effect transistor (smFET) nanotube devices; both generate streams of time-ordered current or voltage data, typically sampled near 1 MS/s, with run times of minutes, yielding terabyte-scale datasets.
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- Designing spray-dried particles for inhalation focuses on achieving specific properties such as ideal aerodynamic diameter and powder dispersibility.
- Leucine is used to enhance bulk powder properties and is co-sprayed with mannitol, a common bulking agent, while varying excipient ratios and processing conditions to understand particle formation dynamics.
- The study found that the crystallization order of leucine and mannitol affects surface composition, with initial leucine saturation being crucial for optimizing the characteristics of the final powder.