[MECHANISMS OF GASTRODUODENAL DYSMOTILITY UNDER STRESS].

Psychogenic stress in rabbits caused dysmotility of the gastroduodenal zone: inhibition of contractile activity (CA) in antral and pyloric parts of the stomach simultaneously with the increase of CA in proximal and distal parts of duodenum. Stress induced inhibition of the gastric contractile activity is substantially "non-adrenergic non-cholinergic" and only in the initial phase of the reaction it appears to be "α-adrenergic". The strengthening of CA in the proximal duodenum resulted from the direct exciting action of endocrine stress factor on the smooth muscle of the gut.

Mechanisms of Discoordination of Contractile Activity in the Gastroduodenal Zone during Psychogenic Stress in Rabbits.

Inhibition of the contractile activity of the stomach induced by psychogenic stress persisted after blockade of muscarinic and nicotinic cholinergic receptors and α2 and β1/β2-adrenergic receptors. Stress-induced increase in contractile activity in the proximal part of the duodenum persisted during blockade of muscarinic and nicotinic cholinergic receptors, β1/β2-adrenergic receptors. At the same time, blockade of the above cholinergic and adrenergic receptors eliminated the stress-induced increase in contractive activity in the distal part of the duodenum.

[Symptoms of circadian desynchronization in patients with multiple sclerosis].

Circadian rhythm of sleep-wakefulness and evacuation function of intestines, symptoms of neuropsychic adaptation were investigated in 36 patients, aged 21-53 years, with multiple sclerosis (MS). Frequencies of circadian rhythm disturbances of brain activity (insomnia in 66% of patients) and circadian rhythm disturbances of intestine evacuation (constipation in 72% of patients) were revealed. Insomnia and irritability in MS patients with bradyenteria occur 1.

[Age bowels bradyarrhythmia as risk factor colorectal cancer].

We studied constipation risk and risk of colorectal cancer for people between 20 and 80 years. It has been shown that risk of constipation occurs 10 years earlier than risk of colon cancer. The maximum occurrence of constipation observed in 40-49 years and colorectal cancer--in 70-80 years.

[Constipation--a risk factor for colorectal cancer].

A new, chronophysiological, conception of constipation is based upon the fundamental principle of the circadian regularity of the bowel evacuatory function. The slowing of the near-day (24 +/- 4 hours) regularity of this function in a form of intestinal bradiarrhythmia is an attribute of constipation. According to epidemiological and endoscopic data, constipation, as the basis of colorectal coprostasis, is one of the main risk factors of colorectal cancer (CRC).