Publications by authors named "K A Schwichtenberg"
Aim: Up to 10% of SARS-CoV-2 infected individuals suffer from post-COVID-19 condition, marked by fatigue and cognitive dysfunction as major symptoms. Longitudinal studies on neuropsychological and clinical trajectories and related brain changes are scarce. Here, we aimed to examine their evolution up to 2 years post-infection.
View Article and Find Full Text PDFObjective: Persisting neurological symptoms after COVID-19 affect up to 10% of patients and can manifest in fatigue and cognitive complaints. Based on recent evidence, we evaluated whether cerebral hemodynamic changes contribute to post-COVID syndrome (PCS).
Methods: Using resting-state functional magnetic resonance imaging, we investigated brain perfusion and oxygen level estimates in 47 patients (44.
Respiratory deficits after C2 hemisection (C2Hx) have been well documented through single-sex investigations. Although ovarian sex hormones enable enhanced respiratory recovery observed in females 2 wk post-C2Hx, it remains unknown if sex impacts spontaneous respiratory recovery at chronic time points. We conducted a longitudinal study to provide a comprehensive sex-based characterization of respiratory neuromuscular recovery for 8 wk after C2Hx.
View Article and Find Full Text PDFPost-COVID-19 syndrome is a serious complication following SARS-CoV-2 infection, characterized primarily by fatigue and cognitive complaints. Although first metabolic and structural imaging alterations in Post-COVID-19 syndrome have been identified, their functional consequences remain unknown. Thus, we explored the impact of Post-COVID-19 syndrome on the functional connectome of the brain providing a deeper understanding of pathophysiological mechanisms.
View Article and Find Full Text PDFArticle Synopsis
- Post-COVID syndrome causes severe long-term fatigue and cognitive issues following COVID-19, with 47 out of 50 patients showing moderate to severe fatigue around 7.5 months post-infection.
- Imaging studies detected structural changes in the thalamus and basal ganglia, indicating potential brain-related causes for the fatigue, which also correlated with factors like sleep quality and anxiety.
- Unlike fatigue in multiple sclerosis, the severity of post-COVID fatigue did not relate to the severity of the original COVID-19 illness, suggesting distinct underlying mechanisms.