Publications by authors named "K A Pathak"
Cytoplasmic proliferating cell nuclear antigen (PCNA) is highly expressed in acute myeloid leukemia (AML) cells, supporting oxidative metabolism and leukemia stem cell (LSC) growth. We report on AOH1996 (AOH), an oral compound targeting cancer-associated PCNA, which shows significant antileukemic activity. AOH inhibited growth in AML cell lines and primary CD34 + CD38 - blasts (LSC-enriched) in vitro while sparing normal hematopoietic stem cells (HSCs).
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- Glyphosate usage has risen significantly in the U.S. since 1996, with research showing it can accumulate in the brain and invoke neuroinflammation, potentially influencing neurodegenerative disorders like Alzheimer's Disease (AD).
- The study involved giving varied doses of glyphosate to both Alzheimer's model mice and control mice, revealing that glyphosate and its metabolite remained detectable in brain tissue even after a recovery period.
- Results indicated that glyphosate exposure led to worsened cognitive function in AD mice, along with significant increases in brain plaque formation, tau protein abnormalities, and persistent inflammatory markers in both mouse groups.
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- * A recent genomic study identified extensively drug-resistant strains of these bacteria from a blood sample of a patient with a specific kidney condition (pauci-immune crescentic glomerulonephritis), utilizing whole-genome sequencing to analyze their characteristics.
- * The analysis revealed distinct genome sizes and features, including multiple virulence factors and antimicrobial resistance mechanisms, emphasizing the need to understand these polymicrobial infections for better treatment strategies.
Introduction: Precise working length control during chemomechanical preparation is one of the primary factors for successful endodontic therapy.
Aim: The study aims to evaluate the postoperative pain after determining working length with an integrated apex locator-endomotor and a separate apex locator-endomotor.
Subjects And Methods: One hundred and twenty subjects with a diagnosis of symptomatic irreversible pulpitis and preoperative pain score Visual Analog Scale (VAS) >50 were allocated into Group I with nonintegrated apex locator and endomotor and Group II with integrated apex locator endomotor, further treated by single endodontist.
Heavy metals are lethal and hazardous pollutants for the ecosystem owing to their virtues including acute toxicity, prolonged persistence, and bioaccumulation. These contaminants are not only a threat to aquatic/terrestrial biota but also pose serious health issues to humans. Natural and anthropologic processes consistently upsurge heavy metal concentration beyond acceptable limits and mobilization and hence disturb biogeochemical cycles and the food chain, although several conventional strategies including adsorption, chemical precipitation, ion exchange, and membrane separation methods are being employed for the removal of these lethal heavy metals from the ecosystem but failed due to lower efficiency rates and high application charges.
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