Publications by authors named "K A Nikolskaya"
[ISSUES OF ROUTING PATIENTS WITH AUTOIMMUNE HEPATITIS].
Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med
October 2024
Autoimmune hepatitis is a chronic, immune-mediated liver disease characterized by an increased level of immunoglobulins G and/or gamma globulins, the presence of autoantibodies and a typical histological picture. Diagnosis of autoimmune hepatitis causes difficulties due to various variants of the course, wide variability of the clinical picture, which leads to a large number of missed cases of the disease. Treatment of аutoimmune hepatitis is aimed at reducing the activity of an inadequate response of the immune system against cells of its own body and achieving complete remission of the disease.
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- * A study evaluated a new Sanger sequencing test on 25 pure culture samples, showing 100% sensitivity for clarithromycin and high sensitivity (93%) and specificity (92%) for levofloxacin resistance detection.
- * In clinical tests on 112 patients, resistance mutations were found in 24% for clarithromycin and 23% for levofloxacin, with specific mutations identified, emphasizing the importance of personalized therapy to combat antibiotic resistance.
Article Synopsis
- The study investigates the relevance of biopsies from the incisura angularis in determining the risk of gastric cancer in patients with chronic gastritis using the OLGA system for assessment.
- A total of 718 patients were examined, aged 20 to 84, and categorized based on the presence of autoimmune gastritis markers, resulting in three distinct patient groups.
- Results showed that grade II inflammatory changes were prevalent (72.3%) across all groups, with severe chronic gastritis activity most common in patients with non-autoimmune gastritis, and these findings remained consistent even when excluding the incisura angularis biopsy.
Unlabelled: was to define the spectrum of genetic risk factors of chronic pancreatitis (CP) development in patients living in the European part of the Russian Federation.
Materials And Methods: The study group included 105 patients with CP, with the age of the disease onset under 40 years old (the average age of onset was 26.9 years).
[WAYS TO SOLVE THE PROBLEM OF HOME PARENTERAL NUTRITION IN PATIENTS WITH SHORT BOWEL SYNDROME].
Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med
December 2022
The purpose of the work is to identify the most optimal ways to solve the problem of home parenteral nutrition for patients with short bowel syndrome.Basics. Discussion of the current situation will help optimize the work of the Orphan Diseases Center, lead to a greater introduction of online technology, and aim at the search and implementation of new methods of treating patients in this category.
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