Genetic variants of Tgfb1 act as context-dependent modifiers of mouse skin tumor susceptibility.

The human TGFB1 gene is polymorphic, and genetic variants are associated with altered cancer risk. However, human genetic association studies have had variable outcomes because TGFbeta1 action is context-dependent. We used the murine skin model of chemical carcinogenesis in genetic linkage analysis of three independent Mus musculus NIH/Ola x (Mus spretus x M.

Comparison of automated and manual ventilation in a prehospital pediatric model.

Objective: Portable transport ventilators (TV) and demand valves (DV) may be effective and easy-to-use alternatives to bag-valve (BV) for prehospital ventilation of adults. The purpose of the study was to determine whether such devices maintain arterial blood gases and airway pressures similar to those for BV in a pediatric swine model.

Method: This study was a prospective, randomized, crossover design using immature swine (9.

Two-thumb versus two-finger chest compression during CRP in a swine infant model of cardiac arrest.

Study Objective: To test the hypothesis that two-thumb chest compression generates higher arterial and coronary perfusion pressures than the current American Heart Association-approved two-finger method.

Design: Randomized, crossover experimental trial.

Setting And Participants: Animal laboratory experiment with seven swine of either sex weighing 9.

An experimental algorithm versus standard advanced cardiac life support in a swine model of out-of-hospital cardiac arrest.

Study Objective: To compare an experimental algorithm with standard advanced cardiac life support in a swine model of out-of-hospital cardiac arrest.

Design: Randomized, controlled experimental trial. SETTING/TYPE OF PARTICIPANT: Animal laboratory using swine.

Molecular dynamics studies of the interface between a model membrane and an aqueous solution.

Molecular Dynamics (MD) computer simulation studies are reported for a system consisting of two model membranes in contact with an aqueous solution. The influence of the membrane on the adjacent liquid is of main interest in the present study. It is therefore attempted to make the system sufficiently large to encompass the entire region between bulk liquid and the membranes.