Publications by authors named "K A McEachern"
Neuropathic pain can be caused by multiple factors, and its prevalence can reach 10% of the global population. It is becoming increasingly evident that limited or short-lasting response to treatments for neuropathic pain is associated with psychological factors, which include psychiatric comorbidities known to affect quality of life. It is estimated that 60% of patients with neuropathic pain also experience depression, anxiety, and stress symptoms.
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- The primary aim of rare plant translocation is to establish self-sustaining populations that can endure over time, but most studies only analyze short-term success metrics like survival and reproduction.
- A comprehensive analysis of 275 monitored at-risk plant translocations revealed that management techniques play a critical role in short-term success, while site attributes and species traits are more significant for long-term population persistence.
- Key findings indicated that larger founder sizes enhance reproductive potential, whereas poor habitat quality and low seed production in species heighten the risk of extinction in the long run; effective management can help mitigate these challenges.
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- Alzheimer's disease (AD) is becoming more common as the population ages, and current treatments are not very effective, prompting studies into new options like transcranial photobiomodulation (t-PBM), which uses near-infrared light to enhance brain function.
- This research involves a double-blind, placebo-controlled trial with participants suffering from amnestic mild cognitive impairment (aMCI) and early AD, testing the effects of 24 t-PBM sessions over 8 weeks on cognition and safety.
- The study aims to determine if t-PBM can effectively improve cognitive functions by also exploring underlying brain mechanisms, making it a potentially affordable and practical treatment for individuals with early signs of AD.
Photobiomodulation: An Emerging Treatment Modality for Depression.
Psychiatr Clin North Am
June 2023
Major depressive disorder (MDD) is considered a global crisis. Conventional treatments for MDD consist of pharmacotherapy and psychotherapy, although a significant number of patients with depression respond poorly to conventional treatments and are diagnosed with treatment-resistant depression (TRD). Transcranial photobiomodulation (t-PBM) therapy uses near-infrared light, delivered transcranially, to modulate the brain cortex.
View Article and Find Full Text PDFPurpose: New immuno-oncology therapies targeting programmed cell death receptor 1 (PD-1) have improved patient outcomes in a broad range of cancers. The objective of this analysis was to evaluate the PK, pharmacodynamics (PDy), and safety of dostarlimab monotherapy in adult patients with previously-treated advanced solid tumors who participated in parts 1 and 2A of the phase 1 GARNET study.
Methods: Part 1 featured a 3 + 3 weight-based dose-escalation study, in which 21 patients received dostarlimab 1, 3, or 10 mg/kg intravenously every 2 weeks.