Greater improvement in insulin sensitivity per unit weight loss associated with tirzepatide versus semaglutide: An exploratory analysis.

Aims: To explore the relationship between weight loss and insulin sensitivity in response to tirzepatide or semaglutide.

Materials And Methods: We conducted a post hoc exploratory analysis of a 28-week, double-blind, randomized trial in people with type 2 diabetes treated with metformin, randomized to tirzepatide 15 mg, semaglutide 1 mg or placebo. We evaluated the relationship between change in body weight and change in insulin sensitivity determined from hyperinsulinemic euglycemic clamp (M value), or from mixed-meal tolerance testing (Matsuda index).

Longitudinal associations between fruit and vegetable intakes and depressive symptoms in middle-aged and older adults from four international twin cohorts.

Beneficial associations between higher fruit and vegetable intakes and risk of depression appear to exist but few studies have focused on adults aged 45 + years and the potential that associations are due to residual confounding has not been tested. This longitudinal study of twins (n = 3483, age 45-90 years) from Australia, Denmark, Sweden and USA, assessed the associations between baseline fruit/vegetable intake and depressive symptoms over 5-11 years using linear mixed effects models. Intakes from food frequency questionnaires were trichotomized.

The cross-cultural big two: A culturally decentered theoretical and measurement model for personality traits.

A "big two" model has shown stronger cross-cultural replicability and links to theory than other contemporary models of personality trait structure. However, its theoretical and measurement models require better specification. We address this to create an initial English-language version of the Cross-Cultural Big Two Inventory with an empirically informed and culturally decentered approach, meaning that input from global contexts is used from the outset, without prioritizing Western perspectives.