Synthesis and Evaluation of a Bifunctional Chelator for Thorium-227 Targeted Radiotherapy.

Thorium-227 (Th) is an α-emitting radionuclide currently under investigation for targeted alpha therapy. Available chelators used for this isotope suffer from challenging multistep syntheses. Here, we present the synthesis and preclinical evaluation of a novel bifunctional chelator, SCN-Bn-DOTHOPO, which contains an isothiocyanate group that is suitable for conjugation to biological molecules.

An aperiodic chiral tiling by topological molecular self-assembly.

Studying the self-assembly of chiral molecules in two dimensions offers insights into the fundamentals of crystallization. Using scanning tunneling microscopy, we examine an uncommon aggregation of polyaromatic chiral molecules on a silver surface. Dense packing is achieved through a chiral triangular tiling of triads, with N and N ± 1 molecules at the edges.

Research Note: Evaluation of selected chlorhexidine salts/product and/or cetylpyridinium chloride as potential pre-slaughter crop disinfection agents using an in vitro assay simulating crop contents.

Salmonellae remain a prominent issue for poultry products regarding food safety. A predominant source of broiler carcass contamination at processing is from crop rupturing and subsequent contamination of the carcass during evisceration. Chlorhexidine (CHX) salts are commonly used in dental products for their antimicrobial capabilities.

Polycomb Repressive Complex 2 promotes atherosclerotic plaque vulnerability.

Atherosclerotic cardiovascular disease (ASCVD), the leading cause of mortality worldwide, is driven by endothelial cell inflammatory activation and counter-balanced by anti-inflammatory transcription factors Klf2 and Klf4 (Klf2/4). Understanding vascular endothelial inflammation to develop effective treatments is thus essential. Here, we identify, Polycomb Repressive Complex (PRC) 2, which blocks gene transcription by trimethylating histone3 Lysine27 in gene promoter/enhancers, as a potent, therapeutically targetable determinant of vascular inflammation and ASCVD progression.

Ngā Māuiui Kai: creating Indigenous Māori terms for eating disorders in Aotearoa New Zealand.

Background: Māori (the Indigenous people of Aotearoa New Zealand) report higher rates of eating disorders than non-Māori, but access treatment at lower rates. Diagnostic terms lacking in cultural relevance likely contribute to Māori exclusion in eating disorder spaces. Developing terms in te reo Māori (the Māori language) presents an opportunity to challenge eating disorder stereotypes and increase cultural safety in the eating disorder workforce.