Publications by authors named "K A MacPherson"
Protein synthesis is frequently deregulated during tumorigenesis. However, the precise contexts of selective translational control and the regulators of such mechanisms in cancer is poorly understood. Here, we uncovered CNOT3, a subunit of the CCR4-NOT complex, as an essential modulator of translation in myeloid leukemia.
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- - Pancreatic cancer treatment is challenging due to limited options and the aggressive nature of the disease, leading researchers to explore the compound juglone as a potential therapy that can inhibit tumor growth and induce cancer cell death.
- - To reduce juglone's toxicity and enhance its effectiveness, researchers developed polymeric micelles using Poloxamer 407 and D-α-Tocopherol polyethylene glycol 1000 succinate, which showed promising results in lab studies by decreasing cancer cell proliferation and increasing apoptosis without toxicity in animal models.
- - In vivo tests indicated that juglone delivered via micelles significantly reduced tumor growth in mice and also altered the tumor microenvironment to boost immune responses, highlighting its potential as a targeted treatment
Three experiments are reported that used a new test of spatial memory in rats. The apparatus used was dual eight-arm radial mazes that were connected at one arm of each maze, with a start arm and doors to each maze. Rats could be forced to go to one maze or the other or could make a free choice between mazes.
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