The Effect of Depression on Total Knee Arthroplasty.

Introduction: Depression is among the most common mental illnesses, with an estimated 8.1% of adults in the United States living with the condition. Despite its prevalence, the effect of depression on surgical outcomes is not well studied.

Predictive modeling of atmospheric nuclear fallout microphysics.

The capability to predict size, composition, and transport of nuclear fallout enables public officials to determine immediate and prolonged guidance in the event of a nuclear incident. Predictive computer models of fallout can also provide useful insight for nuclear forensic response when detailed radiochemical processes can be reliably included. Current post-detonation nuclear fallout models prescribe particle size distributions empirically or semi-empirically, based on measurements across limited conditions pertaining to tests conducted primarily in Nevada and the Pacific.

The Impact of Cardiac Arrhythmias on Total Knee Arthroplasty Outcomes.

Background: Cardiac comorbidities are common in patients undergoing total knee arthroplasty (TKA). While there is an abundance of research showing an association between cardiac abnormalities and poor postoperative outcomes, relatively little is published on specific pathologies. The aim of this study was to assess the impact of cardiac arrhythmias on postoperative outcomes in the setting of TKA.

Metabolomic profiles of intact tissues reflect clinically relevant prostate cancer subtypes.

Background: Prostate cancer (PC) is a heterogenous multifocal disease ranging from indolent to lethal states. For improved treatment-stratification, reliable approaches are needed to faithfully differentiate between high- and low-risk tumors and to predict therapy response at diagnosis.

Methods: A metabolomic approach based on high resolution magic angle spinning nuclear magnetic resonance (HR MAS NMR) analysis was applied on intact biopsies samples (n = 111) obtained from patients (n = 31) treated by prostatectomy, and combined with advanced multi- and univariate statistical analysis methods to identify metabolomic profiles reflecting tumor differentiation (Gleason scores and the International Society of Urological Pathology (ISUP) grade) and subtypes based on tumor immunoreactivity for Ki67 (cell proliferation) and prostate specific antigen (PSA, marker for androgen receptor activity).

A partial human LCK defect causes a T cell immunodeficiency with intestinal inflammation.

Lymphocyte-specific protein tyrosine kinase (LCK) is essential for T cell antigen receptor (TCR)-mediated signal transduction. Here, we report two siblings homozygous for a novel LCK variant (c.1318C>T; P440S) characterized by T cell lymphopenia with skewed memory phenotype, infant-onset recurrent infections, failure to thrive, and protracted diarrhea.