Publications by authors named "K A Loveland"
Introduction: Given the unique experiences of military service members and their families, military-dependent young adults (18-25 years old) with autism spectrum disorder (ASD) and their military or veteran families experience unique barriers to accessing quality mental health care during the transition to adulthood. In fact, developing services to address ASD challenges for military families is a burgeoning area of interest for the department of defense. However, there is a limited knowledge on the specific needs of military families as the young adult's transition outside of high school and lose supports.
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- Kpna4 knock-out (KO) mice display behaviors linked to psychiatric disorders, including anxiety, social interaction issues, and sensorimotor gating problems.
- Contrary to expectations, Kpna4 deficiency leads to increased expression of NF-κB and proinflammatory cytokines, indicating heightened inflammatory responses in the brain areas examined.
- Additional findings suggest that the absence of Kpna4 may enhance polycomb repressor complex 2 (PRC2) activity in glial cells, further contributing to the observed behavioral deficits.
Article Synopsis
- - Autism spectrum disorder (ASD) is a complex condition influenced by genetic and environmental factors, but its connection with metabolic changes is not well understood.
- - A study analyzed plasma samples from 200 children with ASD and 200 typically developing controls to discover specific metabolites that could serve as biomarkers for the disorder.
- - The research found distinct metabolic patterns in ASD children, identifying four significant metabolites, including three fatty acids and the amino acid sarcosine, which may inform future interventions for ASD.
Purpose: As the understanding of autism spectrum disorder (ASD) across the lifespan has increased, so has the number of individuals being identified with ASD for the first time in adulthood. Understanding co-occurring psychiatric conditions in this subset of the ASD population is a growing focus of research; however, little is known about the rate at which psychiatric medications are prescribed to adults with a first-time diagnosis of ASD. The purpose of this study was to examine self-reported medication use in persons diagnosed with ASD in adulthood in a clinic sample (2012-2022) in the United States.
View Article and Find Full Text PDFStudy Question: Does the chemokine/chemokine receptor axis, involved in immune cell trafficking, contribute to the pathology of testicular inflammation and how does activin A modulate this network?
Summary Answer: Testicular chemokines and their receptors (especially those essential for trafficking of monocytes) are elevated in orchitis, and activin A modulates the expression of the chemokine/chemokine receptor network to promote monocyte/macrophage and T cell infiltration into the testes, causing extensive tissue damage.
What Is Known Already: The levels of CC motif chemokine receptor (CCR)2 and its ligand CC motif chemokine ligand (CCL)2 are increased in experimental autoimmune orchitis (EAO) compared with healthy testes, and mice deficient in CCR2 are protected from EAO-induced tissue damage. Activin A induces CCR2 expression in macrophages, promoting their migration.