Two in one: merging photoactivated chemotherapy and photodynamic therapy to fight cancer.

The growing number of cancer cases requires the development of new approaches for treatment. A therapy that has attracted the special attention of scientists is photodynamic therapy (PDT) due to its spatial and temporal resolution. However, it is accepted that this treatment methodology has limited application in cases of low cellular oxygenation, which is typical of cancerous tissues.

[Problems of ethyl glucuronide use in ethanol consumption diagnosis].

Quantitative determination of ethyl glucuronide (EtG) in different biological objects in recent years has been positioned as one of the most reliable biomarkers of unconditional alcohol consumption. The aim of the study is to summarize the analytical methods of alcohol consumption testing with the use of EtG currently available in domestic and foreign literature and to present a schematic overview of possible errors in reproducibility and interpretation of research on EtG results, which may limit their use in forensic medical practice. The main objective is to increase the reliability and validity of EtG as a marker of ethanol consumption.

Optical and scintillation properties of hybrid manganese(II) bromides with formamidinium and acetamidinium cations.

In recent years, hybrid manganese(II) halides (HMHs) have attracted wide attention due to their impressive optical properties, low toxicity, and facile synthetic processibility. Being effective reabsorption-free phosphors, these compounds demonstrate the potential to be used as low-cost solution-processable scintillators. However, most of the HMHs studied to date contain bulk organic cations and, as a result, are characterized by low density and low X-ray stopping power.

[The role of antidiabetic drugs in the treatment of Alzheimer's disease: systematic review].

Recent studies show that Alzheimer's disease (AD) has many common links with conditions associated with insulin resistance, including neuroinflammation, impaired insulin signaling, oxidative stress, mitochondrial dysfunction and metabolic syndrome. The authors conducted an electronic search for publications in the PubMed/MEDLINE and Google Scholar databases using the keywords "amyloid beta", "Alzheimer type-3-diabetes", "intranasal insulin", "metformin", "type 2 diabetes mellitus", "incretins" and "PPARy agonists». A systematic literature search was conducted among studies published between 2005 and 2022.

[Determination of the corpse's stay in the water duration according to maceration degree of its skin].

A serious problem during the postmortem examination of a corpse extracted from the water can be a significant determination of its stay in the water duration. First of all, the signs indicating the presence of a corpse in the water include maceration, according to the severity of which forensic experts often determine how long the corpse stayed in the water. The aim of the study is to summarize the available literature data and propose ways to objectify the determination of a corpse's stay in water duration by the severity of skin maceration.