Loneliness in Middle-Aged and Older Adults: Effects of Social Environments.

Loneliness is a common subjective condition that is associated with distress and negative outcomes for psychosocial functioning and well-being, and it is grounded in destructive or inadequate social functioning. Social interactions are considered one of the key factors determining loneliness, and similarly to social interactions, loneliness can occur in different domains. While a solid body of research is focused on loneliness as a general condition, there are few studies that investigate loneliness from a multidimensional perspective, particularly combining general and domain-specific loneliness.

Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements.

Complex chromosome rearrangements, known as chromoanagenesis, are widespread in cancer. Based on large-scale DNA sequencing of human tumours, the most frequent type of complex chromosome rearrangement is chromothripsis, a massive, localized and clustered rearrangement of one (or a few) chromosomes seemingly acquired in a single event. Chromothripsis can be initiated by mitotic errors that produce a micronucleus encapsulating a single chromosome or chromosomal fragment.

Futurization of Aging: Subjective Beliefs and Effects.

Aging in the face of an increasing population and growing life expectancy is considered one of the major demographic challenges in modern society. Previous research has revealed that quality of life in aging could significantly differ depending on the resources one possesses. However, little attention has been given to the mechanisms of formation of these resources and the role of intentionality.

Causes and consequences of micronuclei.

Micronuclei are small membrane-bounded compartments with a DNA content encapsulated by a nuclear envelope and spatially separated from the primary nucleus. Micronuclei have long been linked to chromosome instability, genome rearrangements, and mutagenesis. They are frequently found in cancers, during senescence, and after genotoxic stress.

UBASH3B-mediated silencing of the mitotic checkpoint: Therapeutic perspectives in cancer.

Defects in mitosis can lead to aneuploidy, which is a common feature of human cancers. Spindle Assembly Checkpoint (SAC) controls fidelity of chromosome segregation in mitosis to prevent aneuploidy. The ubiquitin receptor protein Ubiquitin Associated and SH3 Domain Containing B (UBASH3B) was recently found to control SAC silencing and faithful chromosome segregation by relocalizing Aurora B kinase to the mitotic microtubules.