The MuCAYA Study-Influence of Physical Activity and Metabolic Parameters on the Structure and Function of the Cardiovascular System in Young Athletes.

Exercise has a significant impact on the cardiovascular (CV) health of children and adolescents, with resultant alterations in CV structure and function being evident, even at an early age. Engagement in regular, moderate physical activity (PA) is associated with long-term CV health benefits and a reduced risk of CV disease and mortality later in life. However, competitive sports often involve PA training intensities that are beyond recommended levels for young athletes, potentially leading to adverse CV outcomes.

Correction: New insights on Celtic migration in Hungary and Italy through the analysis of non-metric dental traits.

[This corrects the article DOI: 10.1371/journal.pone.

Oncogene activated human breast luminal progenitors contribute basally located myoepithelial cells.

Background: Basal-like breast cancer originates in luminal progenitors, frequently with an altered PI3K pathway, and focally in close association with genetically altered myoepithelial cells at the site of tumor initiation. The exact trajectory behind this bi-lineage phenomenon remains poorly understood.

Methods And Results: Here we used a breast cancer relevant transduction protocol including hTERT, shp16, shp53, and PIK3CA to immortalize FACS isolated luminal cells, and we identified a candidate multipotent progenitor.

IsopretGO-analysing and visualizing the functional consequences of differential splicing.

Gene Ontology overrepresentation analysis (GO-ORA) is a standard approach towards characterizing salient functional characteristics of sets of differentially expressed genes (DGE) in RNA sequencing (RNA-seq) experiments. GO-ORA compares the distribution of GO annotations of the DGE to that of all genes or all expressed genes. This approach has not been available to characterize differential alternative splicing (DAS).