Publications by authors named "K A Kerr"
Purpose: Neoadjuvant immune checkpoint blockade with nivolumab plus ipilimumab improves overall survival (OS) in non-small cell lung cancer (NSCLC); however, randomized data for resectable lung cancer are limited. We report results from the exploratory concurrently randomized nivolumab plus ipilimumab and chemotherapy arms of the international phase III CheckMate 816 trial.
Methods: Adults with stage IB-IIIA (American Joint Committee on Cancer seventh edition) resectable NSCLC received three cycles of nivolumab once every 2 weeks plus one cycle of ipilimumab or three cycles of chemotherapy (on day 1 or days 1 and 8 of each 3-week cycle) followed by surgery.
SARS-CoV-2 variants are mainly defined by mutations in their spike. It is therefore critical to understand how the evolutionary trajectories of spike affect virus phenotypes. So far, it has been challenging to comprehensively compare the many spikes that emerged during the pandemic in a single experimental platform.
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- Noninvasive ventilation therapy is a key alternative to invasive mechanical ventilation in treating acute respiratory failure, particularly for pediatric patients, and requires effective communication strategies to address challenges like discomfort and anxiety.
- A case study of a 7-year-old girl with pulmonary arterial hypertension revealed that discomfort with the bilevel positive airway pressure mask led to compliance issues.
- The introduction of a novel communication device improved mask compliance, communication clarity, mobility, and reduced anxiety during treatment, suggesting such devices can greatly enhance the overall experience and outcomes for young patients on noninvasive ventilation.