Subject-aware PET Denoising with Contrastive Adversarial Domain Generalization.

Recent advances in deep learning (DL) have greatly improved the performance of positron emission tomography (PET) denoising performance. However, DL model performance can vary a lot across subjects, due to the large variability of the count levels and spatial distributions. A generalizable DL model that mitigates the subject-wise variations is highly expected toward a reliable and trustworthy system for clinical application.

Reducing the dose of oral NSAIDs by use of Feldene Gel: an open study in elderly patients with osteoarthritis.

This open, parallel-group, multicenter study enrolled 191 general practice patients with mild to moderate osteoarthritis (OA) who were taking oral nonsteroidal anti-inflammatory drugs (NSAIDs). One group continued their usual NSAID treatment for 28 days without change in drug or dose. The other group reduced their dose of oral NSAID by a factor of two and concomitantly used 1 g of Feldene Gel, applied topically three or four times daily for 14 days.