Publications by authors named "K A Jarvi"
Introduction: In this study, we aimed to explore whether a Y chromosome microdeletion (YCM) confers adverse effects on surgical sperm retrieval potential and intracytoplasmic sperm injection (ICSI) outcomes in men with azoospermia and severe oligospermia.
Methods: This was a retrospective cohort study, which included infertile men with azoospermia or severe oligospermia who were evaluated for karyotype analysis and YCM testing at a university-affiliated hospital between 2010 and 2022. Outcomes of microdissection testicular sperm extraction (mTESE) for surgical sperm retrieval were compared between men diagnosed with YCM and the control group in which no YCM were found.
Idiopathic secondary azoospermia occurrence in men with oligospermia over time.
J Assist Reprod Genet
August 2024
Article Synopsis
- The study focused on how men with oligospermia (low sperm count) might develop idiopathic secondary azoospermia (ISA) over time, looking for risk factors in a group of 1,056 patients.
- Results showed that men with extremely severe oligospermia (≤1 M/ml) had a significantly higher chance (21.1% after 3-5 years) of developing ISA compared to those with severe (4.8%) and mild oligospermia (0%).
- The findings emphasize the need for sperm banking in men with extremely low sperm counts and low testosterone levels, as they are at a higher risk of becoming azoospermic, while those with >1 M/ml are less
Article Synopsis
- Infertility affects 16% of couples in North America, with male factors responsible for about 30% of infertility cases; testosterone is crucial for sperm production and has been declining due to lifestyle changes.
- A study involving 303 infertile men found a significant relationship between serum vitamin B levels and total testosterone, indicating that higher vitamin B levels may help reduce testosterone deficiency.
- Results suggest that men with higher serum vitamin B levels had lower odds of experiencing testosterone deficiency, indicating potential benefits of vitamin B as a nutritional therapy for male infertility.
Background: Paternal age association with sperm parameters has been previously studied, demonstrating a decrease in semen volume, sperm motility, and sperm morphology, but not in sperm concentration. However, scarce data exists on the individual intra-personal changes in semen parameters with time.
Study Design: Retrospective cohort study.
RASopathies are syndromes caused by congenital defects in the Ras/mitogen-activated protein kinase (MAPK) pathway genes, with a population prevalence of 1 in 1,000. Patients are typically identified in childhood based on diverse characteristic features, including cryptorchidism (CR) in >50% of affected men. As CR predisposes to spermatogenic failure (SPGF; total sperm count per ejaculate 0-39 million), we hypothesized that men seeking infertility management include cases with undiagnosed RASopathies.
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