Publications by authors named "K A Hajjar"
Background: Direct oral anticoagulants (DOACs) reduce the rate of thromboembolism in patients with atrial fibrillation but the benefits and risks in survivors of intracerebral haemorrhage are uncertain. We aimed to determine whether DOACs reduce the risk of ischaemic stroke without substantially increasing the risk of recurrent intracerebral haemorrhage.
Methods: PRESTIGE-AF is a multicentre, open-label, randomised, phase 3 trial conducted at 75 hospitals in six European countries.
Article Synopsis
- * In this condition, retinal pigment epithelial cells lose their anchor to a supportive membrane, become more mobile, and migrate to the retinal surface, which can worsen vision.
- * Research indicates that annexin A2 plays a key role in this process by aiding the movement of these retinal cells when stimulated by specific inflammatory proteins, and targeting these proteins in mice may help reduce the condition's progression.
Understanding the genetic adaptations that occurred as humans migrated out of Africa to higher latitudes helps explain on a population-wide level how UV radiation (UVR) exposure will have varying consequences and benefits in patients of different skin pigmentations. It has been hypothesized that the need for efficient vitamin D synthesis was the primary driver for the skin-lightening process that evolutionarily occurred as humans migrated to higher latitudes. This review analyzes the level of support for the hypothesis that skin lightening occurred to enable adequate vitamin D synthesis in populations that migrated to areas with less UVR.
View Article and Find Full Text PDFThis review explores ferroptosis, a form of regulated cell death reliant on iron-induced phospholipid peroxidation, in diverse physiological and pathological contexts, including neurodegenerative disorders, and ischemia-reperfusion. In the realm of cardiovascular diseases, it significantly contributes to cardiomyopathies, including dilated cardiomyopathy, hypertrophic cardiomyopathy, and restrictive cardiomyopathy. Ferroptosis involves intricate interactions within cellular iron metabolism, lipid peroxidation, and the balance between polyunsaturated and monounsaturated fatty acids.
View Article and Find Full Text PDFArticle Synopsis
- Meningitis is an inflammation of the protective layers around the brain and spinal cord, caused by infections or non-infectious factors like cancer or injuries.
- The review compares tuberculous meningitis (TBM) and non-tuberculous meningitis (NTM), focusing on their clinical features to improve diagnosis.
- Research on the roles of oxidative stress and ferroptosis in TBM suggests new treatment options aimed at reducing damage in the central nervous system.