Publications by authors named "K A Gaptulbarova"
It is known that complete pathomorphological response (pCR) after neoadjuvant therapy (NAC) in patients with breast cancer (BC) correlates with higher rates of recurrence-free and overall survival. In turn, the widespread use of neoadjuvant therapy for the treatment of breast cancer defines the clinical need for prognostic markers of response to ongoing therapy. Currently, some clinicopathological prognostic factors are used to assess the potential benefit of neoadjuvant systemic therapy for female patients, but they have limited applicability.
View Article and Find Full Text PDFArticle Synopsis
- - A new strategy for preventing cancer metastasis involves using a combination of three specific microRNAs (miR-195-5p, miR-520a, and miR-630) that help stop cancer cells from reverting to a stem cell-like state, which is linked to their ability to spread.
- - Researchers conducted transcriptome microarray analysis to observe how these microRNAs affected gene expression in human breast cancer cell lines, finding that the microRNA mixture reduced the cells' ability to form mammosphere clusters in lab conditions.
- - When the microRNAs were delivered in lipid nanoparticles, they effectively prevented lung metastasis in a mouse model, suggesting this combination could lead to promising new treatments that thwart the growth of secondary tumors.
To date, numerous mechanisms have been identified in which one cell engulfs another, resulting in the creation of 'cell-in-cell' (CIC) structures, which subsequently cause cell death. One of the mechanisms of formation of these structures is entosis, which is presumably associated with possible carcinogenesis and tumour progression. The peculiarity of the process is that entotic cells themselves actively invade the host cell, and afterwards have several possible variants of fate.
View Article and Find Full Text PDFBackground: the present study aims to prove or disprove the hypothesis that the state of copy number aberration (CNA) activation of WNT signalling pathway genes accounts for the ability of differentiated tumour cells to emerge from postchemotherapy shock.
Methods: In the first step, the CNA genetic landscape of breast cancer cell lines BT-474, BT-549, MDA-MB-231, MDA-MD-468, MCF7, SK-BR-3 and T47D, which were obtained from ATCC, was examined to rank cell cultures according to the degree of ectopic activation of the WNT signalling pathway. Then two lines of T47D with ectopic activation and BT-474 without activation were selected.
Unlabelled: One of the important reasons for the ineffectiveness of chemotherapy in breast cancer (BC) is considered to be the formation of a multidrug resistance phenotype in tumour cells, which is caused by the expression of energy-dependent ABC transporters. The aim of this work was to assess chromosomal aberrations and the level of transcripts of all 49 known ABC transporter genes in breast tumours.
Materials And Methods: The study included 129 patients with breast cancer.