Publications by authors named "K A Earle"
At the 2023 Global Vaccine and Immunization Research Forum (GVIRF), researchers from around the world gathered in the Republic of Korea to discuss advances and opportunities in vaccines and immunization. Many stakeholders are applying the lessons of Covid-19 to future emergencies, by advancing early-stage development of prototype vaccines to accelerate response to the next emerging infectious disease, and by building regional vaccine research, development, and manufacturing capacity to speed equitable access to vaccines in the next emergency. Recent vaccine licensures include: respiratory syncytial virus vaccines, both for the elderly and to protect infants through maternal immunization; a new dengue virus vaccine; and licensure of Covid-19 vaccines previously marketed under emergency use authorizations.
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- Measles and rubella micro-array patches (MR-MAPs) are innovative alternatives to traditional needle and syringe vaccines, offering single-dose convenience, easier handling, and better temperature stability.
- An initial full value vaccine assessment (iFVVA) evaluated their potential impact, finding that widespread use of MR-MAPs could prevent millions of measles cases, deaths, and years lost to disability by reaching an additional 80 million children over the next decade.
- The assessment also emphasized the need for financial investment in manufacturing and clinical studies, while showing that MR-MAPs have the potential to be cost-effective for routine immunization in many low- and middle-income countries, depending on pricing and coverage uncertainties.*
Article Synopsis
- Aspergillus fumigatus causes the infection known as aspergillosis and uses asexual spores to infect hosts, but little is known about how it evades the immune system.
- In this study, researchers analyzed the conidial surface proteins of A. fumigatus and compared them to two non-pathogenic species, discovering 62 proteins unique to A. fumigatus.
- Testing null mutants for 42 genes revealed that deleting 33 of these genes affected the fungus's ability to resist immune responses, particularly highlighting a gene that influences the proinflammatory cytokine IL-1β, which is crucial for infection in a mouse model.
Two studies were conducted to test the convergence of mass and interpersonal media processes and their effects on YouTube. The first study examined the influence of interpersonal interactions on video enjoyment. The results indicated that positive comment valence affected participants' identification with the content creator, which then affected enjoyment of the video.
View Article and Find Full Text PDFExisting research on parental information literacy focuses on parents' ability to evaluate information. This approach does not account for conflicting or unwanted information and obscures the emotional impact of unsought information. We aimed to (1) document the sources women use most frequently for accessing breastfeeding information, (2) explore the reasons women choose some sources over others, (3) test the relationship between source characteristics and breastfeeding self-efficacy, and (4) determine the extent to which four source characteristics - competence, trustworthiness, goodwill, and social support - predict breastfeeding self-efficacy.
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