[Estimation of treatment of efficiency of destructive periodontitis by osteoplastic material TrApeks-gel].

Tusk of the present research was clinical estimation of conservative treatment of periodontitis by new medicinal preparation developed specially for endodontics by Joint-stock company NPO "Polystom". TrApeks-gel - material for emporary sealing of root channels contained complex composition from osteoplastic materials and special additives: gel-forming material, hydroxyapatite, nanodisperse admixture fractions of orthophosfates calcium, antioxidants, antiinflammatory and radiopaque substances on geliobase. After the standard scheme of chemo-mechanical preparing of root channels of 46 patients (49 teeth) 2 groups were allocated.

[Supramolecular complex of extracellular bone matrix initiating biological mineralization].

A water insoluble supramolecular complex was isolated from bovine mature compact bone. It consists of approximately equal amounts of collagen, Ca-binding proteins and polar lipids that stimulate precipitation of calcium orthophosphates and their transformation into hydroxyapatite. Mechanism of participation of this complex in biological mineralization under physiological conditions and heterotopical calcification is discussed.

[Noncollagen bone proteins use in the composition of osteoplactic material Gapkol modified by vacuum].

In rat experiments the ability of noncollagen bone proteins (NCBP) in the composition of osteoplactic modified material Gapkol (not tanned in formalin and subjected to vacuum extraction) to increase bone reparation in comparison with traditional Gapkol was studied. Quantitative evaluation was performed on rat parietal bone and qualitative evaluation was performed on rat mandible. It was shown that Gapkol with NCBP (not tanned in formalin and subjected to vacuum extraction) increased reparative osteogenesis.

[Effects of the composition of bone tissue growth factors on cell growth on the model of long term culture of the bone marrow].

The experimental study of the properties of the collagen- and hydroxyapatite-containing osteoplastic material HAPKOL-I by bone marrow hemopoiesis was made in comparison with existing material HAPKOL. HAPKOL-I is a working name of the material consisting of HAPKOL and composition of non-collagen bone proteins produced from xenogenic bone material. Long-term cultures of bone marrow from mice (C57B1/6xCBA)F1 of dexter type were used.

[Regulation of distractional osteogenesis: biochemical aspects].

The samples of intact compact bone, bone tissue of new-born puppies (BP), distractional regenerate bone (DRB), new cancellous bone (NCB) filling in the transported fragment were fractionated by the degree of maturity while substituting canine tibial shaft defect using bifocal distraction-compression osteosynthesis. Comparative analysis of the composition of the mineral phase and the organic matrix of different derivatives of bone tissue revealed the identity of low-mineralized fractions of BP and NCB. It was suggested that the fractions were produced by DRB cells which were phenotypically different from osteogenic ones.