Identification and Evaluation of Reversible Covalent Binders to Cys55 of Bfl-1 from a DNA-Encoded Chemical Library Screen.

Bfl-1 is overexpressed in both hematological and solid tumors; therefore, inhibitors of Bfl-1 are highly desirable. A DNA-encoded chemical library (DEL) screen against Bfl-1 identified the first known reversible covalent small-molecule ligand for Bfl-1. The binding was validated through biophysical and biochemical techniques, which confirmed the reversible covalent mechanism of action and pointed to binding through Cys55.

Special Issue "Sympathetic Nerves and Cardiovascular Diseases".

Cardiovascular diseases (CVDs) constitute a spectrum of disorders affecting the heart and blood vessels, which include coronary heart disease, cerebrovascular disease, and peripheral artery disease [...

On random conformity bias in cultural transmission of polychotomous traits.

Mathematical models of conformity and anti-conformity have commonly included a set of simplifying assumptions. For example, (1) there are m=2 cultural variants in the population, (2) naive individuals observe the cultural variants of n=3 adult "role models," and (3) individuals' levels of conformity or anti-conformity do not change over time. Three recent theoretical papers have shown that departures from each of these assumptions can produce new population dynamics.