Publications by authors named "K A Deichmann"
IL-33 is a tissue-derived cytokine that induces and amplifies eosinophilic inflammation and has emerged as a promising new drug target for asthma and allergic disease. Common variants at IL33 and IL1RL1, encoding the IL-33 receptor ST2, associate with eosinophil counts and asthma. Through whole-genome sequencing and imputation into the Icelandic population, we found a rare variant in IL33 (NM_001199640:exon7:c.
View Article and Find Full Text PDFBackground: Concomitant administration of vaccines can facilitate vaccination uptake, provided that no clinically significant effect on either vaccine is identified. We investigated the concomitant administration, during the second year of life, of one dose of the combined measles, mumps, rubella and varicella vaccine (ProQuad(®)) with a booster dose of a hexavalent vaccine.
Methods: In this multicentre, open-label study, participants were randomized to 3 groups: Group 1, concomitant administration of one dose of ProQuad(®) and a booster of hexavalent vaccine; Group 2, one dose of ProQuad(®) alone; Group 3, a booster dose of hexavalent vaccine alone.
Article Synopsis
- - The study investigates the genetic and environmental risk factors for asthma by analyzing data from 5,416 individuals of different ethnic backgrounds, including European American, African American, and Latino ancestry, and replicating findings in 12,649 additional individuals.
- - Researchers identified five genetic loci linked to asthma susceptibility, confirming four previously known associations and discovering a new one at the PYHIN1 gene, specific to individuals of African descent.
- - The findings highlight that while some genetic risk factors for asthma are consistent across various ancestries, there are also specific associations that vary depending on ethnic background, suggesting a complex genetic landscape for the disease.
A sequence variant (rs7216389-T) near the ORMDL3 gene on chromosome 17q21 was recently found to be associated with childhood asthma. We sought to evaluate the effect of rs7216389-T on asthma subphenotypes and its correlation with expression levels of neighboring genes. The association of rs7216389-T with asthma was replicated in six European and one Asian study cohort (N=4917 cases N=34 589 controls).
View Article and Find Full Text PDFEffect of rapid influenza testing on the clinical management of paediatric influenza.
Influenza Other Respir Viruses
May 2009
Background: Rapid tests are now widely available to assist the diagnosis of influenza; implementation may optimise the use of antiviral and antibiotic agents in the clinical management of influenza.
Objective: To explore the clinical management of children with influenza-like illness (ILI) when rapid influenza tests were and were not performed.
Methods: Between 15 January 2007 and 30 April 2007, a standardised questionnaire was used to record the clinical features of children aged 1-12 years who presented to office-based paediatricians in Germany with febrile ILI during periods of local influenza activity.