Publications by authors named "K A Cushing"
Insulin resistance (IR) is a well-established risk factor for metabolic disease. The ratio of triglycerides to high-density lipoprotein cholesterol (TG:HDL-C) is a surrogate marker of IR. We conducted a genome-wide association study of the TG:HDL-C ratio in 402,398 Europeans within the UK Biobank.
View Article and Find Full Text PDFInflammatory bowel disease (IBD) represents a spectrum of disease, which is characterized by chronic gastrointestinal inflammation. Monogenic mutations driving IBD pathogenesis are more highly represented in early-onset compared to adult-onset disease. The pathogenic genes which dysregulate host immune responses in monogenic IBD affect both the innate (ie, intestinal barrier, phagocytes) and adaptive immune systems (ie, T cells, B cells).
View Article and Find Full Text PDFArticle Synopsis
- Patients with inflammatory bowel disease (IBD) have a higher risk of co-morbid diseases, but the effectiveness of their treatments in these patients is not well-understood.
- This study aimed to assess how long different IBD medications are effective in patients with co-existing conditions like psoriasis, rheumatoid arthritis, or enteropathic arthritis compared to those with IBD alone.
- The results indicated that patients with psoriasis tended to have longer medication use duration for most therapies, although not all differences were statistically significant, especially for patients with ulcerative colitis and Crohn's disease.
Introduction: School-based health centers (SBHCs) provide students with critical, cost-effective access to health care. The pandemic accelerated a shift in SBHC care delivery. From the viewpoint of SBHC state leadership, this study aimed to describe changes since the last national SBHC health policy survey in 2017 through the COVID-19 pandemic.
View Article and Find Full Text PDFBackground & Aims: Non-alcoholic fatty liver disease (NAFLD) can progress to cirrhosis and hepatic decompensation, but whether genetic variants influence the rate of progression to cirrhosis or are useful in risk stratification among patients with NAFLD is uncertain.
Methods: We included participants from 2 independent cohorts, they Michigan Genomics Initiative (MGI) and UK Biobank (UKBB), who had NAFLD defined by elevated alanine aminotransferase (ALT) levels in the absence of alternative chronic liver disease. The primary predictors were genetic variants and metabolic comorbidities associated with cirrhosis.