Publications by authors named "K A Cornell"
Background: A study of topical Sildenafil Cream 3.6% was completed among healthy premenopausal women with female sexual arousal disorder.
Aims: To compare efficacy endpoints based on product use in pre-planned and post-hoc subsets of age, race, and medication use.
Autofluorescence-guided Removal of Bacterial Biofilms from Tissues Using Cold Atmospheric Pressure Plasma (CAP).
IEEE Trans Radiat Plasma Med Sci
November 2024
Cold atmospheric pressure plasma (CAP) has the potential to completely remove biofilms from surfaces. The goal of this study is to employ the autofluorescence nature of bacterial biofilms to guide the removal of these biofilms using a CAP scalpel. biofilms, which produce a green fluorescence under 405 nm UV light, were grown on 12 chicken samples.
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- ALS is a severe neurodegenerative disease that leads to paralysis and death, with its genetic causes not fully understood.
- Researchers conducted a study involving 435 ALS patients and 279 controls to identify genetic risk factors, using methods like GWAS and TWAS to analyze gene variants and their effects.
- The study found a significant variant linked to increased ALS risk and indicated that certain genetic factors might reduce the risk, highlighting the need for further research into these genetic and environmental interactions.
Article Synopsis
- Research is focused on finding new biologically active compounds, specifically Azothioformamides (ATFs), which can form stable coordination complexes with metals like copper for potential anticancer and antimicrobial therapies.
- In this study, different ATF ligands with varying heterocyclic groups were synthesized and complexed with Cu(I) salts, which were chosen for their potential lower toxicity and effective binding properties.
- The results indicated that smaller pyrrolidine-substituted ATFs showed stronger binding to Cu(I) salts and had varying levels of antimicrobial activity, particularly against some cancer cell lines, while the ATF ligands alone showed limited effectiveness.
Background: There are currently no Food and Drug Administration-approved treatments for female sexual arousal disorder (FSAD), which is physiologically analogous to male erectile dysfunction.
Aims: The study sought to test the systemic and local genital safety of topical sildenafil cream, 3.6% (sildenafil cream) among healthy premenopausal women with FSAD and their sexual partners over a 12-week treatment period.