Publications by authors named "K A Cassady"
Background: Post-hemorrhagic hydrocephalus (PHH) is a severe complication in premature infants following intraventricular hemorrhage (IVH). It is characterized by abnormal cerebrospinal fluid (CSF) accumulation, disrupted CSF dynamics, and elevated intracranial pressure (ICP), leading to significant neurological impairments.
Objective: This review provides an overview of recent molecular insights into the pathophysiology of PHH and evaluates emerging therapeutic approaches aimed at addressing its underlying mechanisms.
High-grade gliomas (HGGs) and glioblastomas (GBMs) are the most aggressive and lethal brain tumors. The current standard of care (SOC) includes gross safe surgical resection followed by chemoradiotherapy. The main chemotherapeutic agents are the DNA-alkylating agent temozolomide (TMZ) and adjuvants.
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- Malignant peripheral nerve sheath tumors (MPNST) are tough to treat because they often come back after surgery and don't respond well to regular chemotherapy.
- A new treatment called oncolytic viroimmunotherapy, which uses viruses to help fight tumors, shows promise but doesn’t work for everyone, so more research is needed to improve it.
- In experiments, using specific drugs along with the oncolytic virus helped some mice live longer by boosting their immune response against the tumors, leading to less suppressive cells in the tumor area, though the tumors didn’t shrink.
The locus coeruleus (LC) produces the neuromodulators norepinephrine and dopamine, and projects widely to subcortical and cortical brain regions. The LC has been a focus of neuroimaging biomarker development for the early detection of Alzheimer's disease (AD) since it was identified as one of the earliest brain regions to develop tau pathology. Our recent research established the use of positron emission tomography (PET) to measure LC catecholamine synthesis capacity in cognitively unimpaired older adults.
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