Practical Approaches to Continuous Glucose Monitoring in Primary Care: A UK-Based Consensus Opinion.

Introduction: Type 2 diabetes (T2D) imposes significant personal challenges and societal costs. Continuous glucose monitoring (CGM) is recognised as a state-of-the-art tool, but remains underutilised. Adoption of CGM in primary care should be informed by a broader understanding of the technology's capabilities and limitations.

Coming to my own wisdom: A qualitative study exploring the role of the Take Charge intervention in stroke recovery.

Objective: The Take Charge intervention, delivered early after hospital discharge following acute stroke, is effective at improving 12-month health status, independence and advanced activities of daily living. This study aims to provide a deeper understanding of the experiences of receiving Take Charge.

Design: This was a qualitative study nested within a large randomised control trial, the Taking Charge After Stroke (TaCAS) study.

Direct cytosol delivery of mRNA by micron-sized co-assembly with designer oligopeptides.

Inefficient endosomal escape has been regarded as the main bottleneck for intracellular nucleic acid delivery. While most research efforts have been spent on designing various nano-sized particles, we took a different path here, investigating micron-sized carriers for direct cytosol entry. Using the spontaneous co-assembly of mRNA and the designer 27 amino acid oligopeptide named pepMAX2, micron-sized co-assemblies were obtained with various sizes by altering the concentration of NaCl salt and time for pre-incubation.

Cancer clinical trial participation: a qualitative study of Black/African American communities' and patient/survivors' recommendations.

Background: Black/African Americans experience disproportionate cancer burden and mortality rates. Racial and ethnic variation in cancer burden reflects systemic and health-care inequities, cancer risk factors, and heredity and genomic diversity. Multiple systemic, sociocultural, economic, and individual factors also contribute to disproportionately low Black/African American participation in cancer clinical trials.

Megastigmane and hydroxybenzoic acid derivatives from aqueous leaves extract of lam.

The hot water extract of senescent leaves from is used in traditional Sri Lankan medicine for treating diabetes mellitus. This study aimed to isolate phytochemicals in the ethyl acetate soluble fraction of the hot water extract. Bioassay-guided fractionation led to the isolation of three megastigmane derivatives and two hydroxybenzoic acid derivatives from fractions, demonstrating both hypoglycaemic and antidiabetic activities.