Validation of centrifugation as a countermeasure for otolith deconditioning during spaceflight: preliminary data of the ESA SPIN study.

In the framework of further space exploration, countermeasures to combat the drawbacks of human space flights are essential. The present study focuses on the influence of microgravity on the otolith-ocular reflex and aims to test the hypothesis of artificial gravity being an adequate countermeasure for the deconditioning of the aforementioned reflex. The so-called SPIN study, commissioned by the European Space Agency, can be considered as a control experiment in the broad sense for the Neurolab mission (STS-90) during which 4 crewmembers of the space shuttle were subjected to in-flight centrifugation on the visual and vestibular investigation system (VVIS).

No effects of anti-motion sickness drugs on vestibular evoked myogenic potentials outcome parameters.

Objective: To investigate the effects of meclizine (50 mg), baclofen (10 mg), cinnarizine (20 mg) + dimenhydrinate (40 mg), and promethazine (25 mg) + dextro-amphetamine (5 mg) on the parameters of the vestibular evoked myogenic potential (VEMP) test.

Study Design: Double-blind placebo-controlled prospective randomized trial.

Setting: University hospital.

Reliability of utricular function testing sinusoidal translation profile during unilateral centrifugation.

The unilateral centrifugation test is one of the few vestibular tests that evaluate the utricles side by side. During this test, a subject is rotated about an earth vertical axis at high rotation speeds (e.g.

A new model for utricular function testing using a sinusoidal translation profile during unilateral centrifugation.

The utricle plays an important role in orientation with respect to gravity. The unilateral centrifugation test allows a side-by-side investigation of both utricles. During this test, the subject is rotated about an earth-vertical axis at high rotation speeds (e.

The temporal patterns of c-Fos and basic fibroblast growth factor expression following a unilateral anteromedial cortex lesion.

Following a unilateral anteromedial cortex lesion, a critical period of 12 h to 6 days exists during which the recovery process is exquisitely vulnerable to manipulation. Certain anti-convulsant drugs, as well as convulsive seizures impede recovery when administered during, but not after, the critical period. The mechanisms underlying these behavioral phenomena have not been delineated.