Publications by authors named "K A Aromolaran"
Heart failure with preserved ejection fraction (HFpEF) is increasing at an alarming rate worldwide, with limited effective therapeutic interventions in patients. Sudden cardiac death (SCD) and ventricular arrhythmias present substantial risks for the prognosis of these patients. Obesity is a risk factor for HFpEF and life-threatening arrhythmias.
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- Diabetes patients have a higher risk (~50%) of sudden cardiac death primarily due to ventricular arrhythmias, with the proinflammatory lipid mediator leukotriene B4 (LTB4) playing a significant role.
- In studies using guinea pig hearts, it was found that elevated LTB4 in diabetic models leads to harmful heart rhythms and decreases critical potassium current, affecting heart function.
- The research indicates that targeting LTB4 receptors could be a promising therapeutic strategy to improve heart health and reduce the risk of sudden cardiac death in diabetes patients.
Article Synopsis
- - Obesity is a major and growing global health issue, affecting over 600 million adults and projected to double by 2030, with significant implications for heart health, particularly concerning arrhythmias in those with long QT syndrome.
- - The excess fat in obese individuals triggers chronic inflammation through the release of IL-6, a cytokine that increases the risk of severe heart diseases and arrhythmias by altering heart function.
- - Despite promising results from the IL-6 inhibitor olamkicept in treating other inflammatory conditions, the specific link between IL-6 trans-signaling and heart rhythm disturbances in obesity has yet to be fully investigated, highlighting a crucial area for future research.
Obesity is a major risk factor for the development of life-threatening malignant ventricular tachyarrhythmias (VT) and sudden cardiac death (SCD). Risks may be highest for patients with high levels of the proinflammatory cytokine interleukin (IL)-6. We used our guinea pig model of high-fat diet (HFD)-induced arrhythmias that exhibit a heightened proinflammatory-like pathology, which is also observed in human obesity arrhythmias, as well as immunofluorescence and confocal microscopy approaches to evaluate the pathological IL-6 trans-signaling function and explore the underlying mechanisms.
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- Human brains take a long time to grow and develop compared to most animals.
- Scientists found that the slow development of brain cells in humans is controlled by a special "timer" inside the cells, but they’re not sure exactly how it works yet.
- They discovered that certain chemical changes in cells help set this slow growth pattern, and by changing these chemicals, they could make brain cells mature faster than usual.