Publications by authors named "K A Antonov"
Article Synopsis
- Enzymatic transglycosylation of a specific fleximer base using recombinant purine nucleoside phosphorylase (PNP) resulted in the production of both expected and unexpected reaction products, including N1-pyrazole nucleosides and novel derivatives.
- The study revealed that certain minor products, like a 4-imino-pyridinium riboside and bis-ribose derivatives, were formed, while a particular expected product (4-imino-pyridinium deoxyriboside) was absent.
- Molecular modeling helped identify how the structure of the heterocyclic substrates interacts with the PNP active site, suggesting that the spatial arrangement may facilitate secondary glycosylation, leading to
1,2,4-Triazole derivatives have a wide range of biological activities. The most well-known drug that contains 1,2,4-triazole as part of its structure is the nucleoside analogue ribavirin, an antiviral drug. Finding new nucleosides based on 1,2,4-triazole is a topical task.
View Article and Find Full Text PDFThe authors would like to make the following corrections to the published paper [...
View Article and Find Full Text PDFThirty years, 1993-2023, is a huge time frame in science. We address some major developments in the field of evolutionary algorithms, with applications in parameter optimization, over these 30 years. These include the covariance matrix adaptation evolution strategy and some fast-growing fields such as multimodal optimization, surrogate-assisted optimization, multiobjective optimization, and automated algorithm design.
View Article and Find Full Text PDFTwo forms were found in the NMR spectra of N-substituted 2-chloroadenosines. The proportion of the mini-form was 11-32% of the main form. It was characterized by a separate set of signals in COSY, N-HMBC and other NMR spectra.
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