One-Pot Reaction Sequence: -Acylation/Pictet-Spengler Reaction/Intramolecular [4 + 2] Cycloaddition/Aromatization in the Synthesis of β-Carboline Alkaloid Analogues.

One-pot synthesis of tetrahydro-β-carbolines, fused with an isoindole core, was proposed starting from maleic anhydride and azomethines easily available from tryptamines and 3-(hetaryl)acroleins. This sequence includes four key steps: an acylation of the aldimine with maleic anhydride, a Pictet-Spengler cyclization, an intramolecular Diels-Alder reaction, and a concluding [1,3]- shift. As a result, six- or seven-nuclear alkaloid-like heterocyclic systems, containing a benzo[1,2]indolizino[8,7-]indole fragment annulated with furan, thiophene, or pyrrole, are formed in a diastereoselective manner.

Domino Three-Component -Acylation/[4 + 2] Cycloaddition/Alder-ene Synthesis of Polysubstituted Benzo[]isoindole-4-carboxylic Acids.

Diversely substituted, partially saturated benzo[]isoindole-4-carboxylic acids were synthesized by a new three-component reaction (3CR) starting from cinnamic amines (3-arylallylamines), maleimides, and maleic anhydride. The process consists of -acylation of the amines by maleic anhydride, intramolecular [4 + 2] cycloaddition in vinylarenes (the IMDAV reaction), and the concluding Alder-ene reaction between Diels-Alder intermediates and maleimides. All of the reaction steps proceed in a highly regio- and stereoselective manner, furnishing five adjacent chiral centers and leading to a single diastereoisomer of the title compound.

Analysis and Forecast of the Poverty Rate in the Arctic Zone of the Republic of Sakha (Yakutia).

The article analyzes the indicators of the poverty level in the regions of the Arctic zone of the Russian Federation, and assesses the level of poverty and quality of life in the Arctic zone of Yakutia. The results of sociological studies on the level of poverty in the Arctic regions are presented as well as the measures for its reduction associated with addressing the problems of employment, increasing incomes of the population, and the development of traditional crafts.

(3a,4,5,6,7a)-4,5-Di-bromo-2-[4-(tri-fluoro-meth-yl)phen-yl]-2,3,3a,4,5,6,7,7a-octa-hydro-3a,6-ep-oxy-1-isoindol-1-one: crystal structure and Hirshfeld surface analysis.

The asymmetric unit of the title compound, CHBrFNO, consists of two crystallographically independent mol-ecules. In both mol-ecules, the pyrrolidine and tetra-hydro-furan rings adopt an envelope conformation. In the crystal, mol-ecule pairs generate centrosymmetric rings with (8) motifs linked by C-H⋯O hydrogen bonds.

Crystal structure and Hirshfeld surface analysis of dimethyl (1*,3a*,3a *,6a*,9*,9a*)-3a,5,6,9a-tetra-hydro-1,4,9-1,3a:6a,9-di-epoxy-phenalene-2,3-di-carboxyl-ate.

The title di-epoxy-phenalene derivative, CHO, comprises a fused cyclic system containing four five-membered rings (two di-hydro-furan and two tetra-hydro-furan) and one six-membered ring (cyclo-hexa-ne). The five-membered di-hydro-furan and tetra-hydro-furan rings adopt envelope conformations, and the six-membered cyclo-hexane ring adopts a distorted chair conformation. Two methyl carboxyl-ate groups occupy adjacent positions (2- and 3-) on a tetra-hydro-furan ring.