Publications by authors named "K A Aldeen"

Article Synopsis
  • Connective tissue growth factor (CTGF) can enhance wound healing, but its clinical use is limited due to low stability and difficulty keeping effective concentrations at the wound site.* -
  • Researchers created double-emulsion nanoparticles using alginate and alginate sulfate with polycaprolactone (PCL) for controlled delivery of CTGF, showing good stability, cytocompatibility, and effective wound healing capabilities in cell models and murine models.* -
  • The study found that these nanoparticles promote faster cell migration and significantly improve wound closure in vivo compared to untreated CTGF, offering a promising approach for delivering growth factors and aiding in various medical treatments.*
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The invasion of Ukraine has unleashed a humanitarian crisis and the impact is devastating for millions displaced in Ukraine and for those fleeing the country. Receiving countries in Europe are reeling with shock and disbelief and trying at the same time to grapple with the reality of providing for a large, unplanned, unprecedented number of refugees mainly women and children on the move. Several calls for actions, comments and statements express outrage, the risks, and the impending consequences to life and health.

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Microglia, the resident phagocytes of the central nervous system and one of the key modulators of the innate immune system, have been shown to play a major role in brain insults. Upon activation in response to neuroinflammation, microglia promote the release of inflammatory mediators as well as promote phagocytosis. Plasma prekallikrein (PKall) has been recently implicated as a mediator of neuroinflammation; nevertheless, its role in mediating microglial activation has not been investigated yet.

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