Bovine Serum Albumin-Templated Synthesis of Manganese-Doped Copper Selenide Nanoparticles for Boosting Targeted Delivery and Synergistic Photothermal and Photodynamic Therapy.

Multifunctional nanohybrids integrating diagnostic imaging with photodynamic or photothermal therapy in a single agent feature the next generation of on-demand nanomedicine to meet the challenges in cancer therapy. In the present study, bovine serum albumin (BSA) protein through one pot biomimetic mineralization at its metal binding site synthesized and stabilized manganese-doped copper selenide nanoparticles (Mn:CuSe) with excellent biocompatibility, near-infrared absorption, water solubility, and rich functional groups for further bioconjugation. Mn doping not only imparted the magnetic resonance imaging (MRI) function to the Mn:CuSe@BSA but also enhanced its heat generation ability.

Synthesis of magnetofluorescence Gd-doped CuInS2/ZnS quantum dots with enhanced longitudinal relaxivity.

In this paper, we describe the rapid microwave-assisted synthesis of Gd(3+)-doped CuInS2 (Gd:CIS) quaternary quantum dots (q-dots), which integrate the functions of optical fluorescence and magnetic resonance imaging. Through passivation of ZnS shells around Gd:CIS cores, high-quality and robust photostable Gd:CIS/ZnS core/shell q-dots with enhanced quantum yields were obtained. The intensity and peak-to-peak linewidth of the electron spin resonance (EPR) signal were found to vary depending on the Gd(3+) concentration of Gd:CIS/ZnS.