Intrauterine growth restriction neonates present with increased angiogenesis through the Notch1 signaling pathway.

Intrauterine growth restriction (IUGR) is associated with increased perinatal mortality and morbidity, and plays an important role in the development of adult cardiovascular diseases. This study brings forward a hypothesis that Human umbilical vein endothelial cells (HUVECs) from IUGR newborns present dysfunctions and varying changes of signaling pathways as compared to the Control group. Similar pathways may also be present in pulmonary or systemic vasculatures.

Children hospitalized for juvenile arthritis in the United States.

Juvenile arthritis (JA) is an autoimmune condition affecting children. We used the 2017 National Inpatient Sample (NIS) to evaluate the impact of JA in the United States. The admission data were converted to weighted form and patients between the ages of 0 and 18 (inclusive) were used in our study.

An Update on the Burden of Neonatal Abstinence Syndrome in the United States.

Objectives: To provide an estimate on the most recent burden of neonatal abstinence syndrome (NAS) in the United States.

Methods: The 2016 Kids' Inpatient Database, provided by the Healthcare Cost and Utilization Project and Agency for Healthcare Research and Quality and its partners, was used to identify patients with NAS in the United States. The data consisted of pediatric admissions from 4200 US hospitals recorded between January 1, 2016, and December 31, 2016.

Intrauterine Growth Restriction Programs Intergenerational Transmission of Pulmonary Arterial Hypertension and Endothelial Dysfunction via Sperm Epigenetic Modifications.

Intrauterine life represents a window of phenotypic plasticity which carries consequences for later health in adulthood as well as health of subsequent generations. Intrauterine growth-restricted fetuses (intrauterine growth restriction [IUGR]) have a higher risk of pulmonary arterial hypertension in adulthood. Endothelial dysfunction, characterized by hyperproliferation, invasive migration, and disordered angiogenesis, is a hallmark of pulmonary arterial hypertension pathogenesis.

Kawasaki disease among children in the United States.

Kawasaki disease (KD) is a medium-sized-vessel vasculitis that affects mostly children. The 2016 Healthcare Cost and Utilization Project Kid's Inpatient Database (HCUP KID) was used in weighted form to investigate differences in gender, month of year, race, region, total charges, and household income in the United States. 5503 weighted cases were found.

An update on admissions of cystic fibrosis children in the United States based on national databases.

We read the article posted by Vadagam et al. with great interest and would like to provide a brief update based on the 2016 KID database to understand the trend in hospitalization among cystic fibrosis children.