Functional analysis of the methylerythritol phosphate pathway terminal enzymes IspG and IspH from .

Unlabelled: Isoprenoids are a diverse family of compounds that are synthesized from two isomeric compounds, isopentenyl diphosphate and dimethylallyl diphosphate. In most bacteria, isoprenoids are produced from the essential methylerythritol phosphate (MEP) pathway. The terminal enzymes of the MEP pathway IspG and IspH are [4Fe-4S] cluster proteins, and in the substrates of IspG and IspH accumulate in cells in response to O, suggesting possible lability of their [4Fe-4S] clusters.